Cerebrospinal fluid miRNA Profiling of dogs With and Without Osseous associated Cervical Spondylomyelopathy. Journal of Veterinary Internal Medicine (2019)
Vansteenkiste DP, Fenger JM, Fadda P, Martin-Vaquero P, da Costa RC. Cerebrospinal fluid miRNA Profiling of dogs With and Without Osseous associated Cervical Spondylomyelopathy. Journal of Veterinary Internal Medicine. v. 33, n.6, 2685-2692, 2019
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Disponível em: Inglês
Total de Páginas: 8
Background: Osseous-associated cervical spondylomyelopathy (OA-CSM) is a common condition of the cervical vertebral column that affects giant dog breeds. Micro-RNAs (miRNAs) are small RNAs that regulate gene expression, and recent data suggest that circulating miRNAs present in biological fluids may serve as potential biomarkers for disease. The miRNA profiles of cerebrospinal fluid (CSF) from healthy dogs and dogs clinically affected by OA-CSM have not been described. Objective: To characterize the expression levels of miRNAs present in the CSF of normal Great Danes and identify differentially expressed miRNAs in the CSF of Great Danes clinically affected with OA-CSM.